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Drawing on ethnographic observations in over 290 clinical team meetings and covering a range of conditions from inherited heart disease, cancer, developmental delays and dysmorphia, this paper seeks to explore professional decision making around clinical genomic sequencing. With a specific focus on decisions about a particular kind of ambiguous result ?€¡° called Variants of Uncertain Significance (VUS) ?€¡° this paper examines the role of the perceived ?€?actionability?€? of specific genomic results. The key insight centres on the way in which clinicians?€? beliefs about how parents will react to a result feed back into decisions about the status of such ambiguous results, builds on previous STS work around actionability from Nicole Nelson, Alberto Cambrosio and Stefan Timmermans.